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In November 2012, Washington State voters passed Initiative 502 (I-502), which legalized limited possession, private use, and commercial sales of cannabis for adults. In this report, using national survey data between 2004 to 2019, we compared changes in the rates of reported cannabis, alcohol, and other substance use in Washington relative to comparable states after the enactment of I-502 and the advent of a licensed retail market. We do not find evidence that the enactment of I-502 or the advent of cannabis retail sales in Washington significantly changed reported adult or youth cannabis use, alcohol use, or other substance use compared to non-legalizing states.